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Redaktor Naczelna ogłasza konkurs na najlepszą studencką pracę oryginalną. Szczegółowe informacje znajdują się tutaj.
Pismo Towarzystwa Internistów Polskich, założone przez prof. Władysława Antoniego Gluzińskiego
Pismo indeksowane w:
MEDLINE/Index Medicus,
EMBASE/Excerpta Medica Database,
Index Copernicus (IC), KBN/MNiSW,
Polish Medical Library (GBL), EBSCO,
ISI Science Citation Index Expanded,
Scopus,
Directory of Open Access Journals (DOAJ)
Wartość Index Copernicus (IC) za 2010: 9 pkt,
punktacja MNiSW: 9 pkt.
Czasopismo dofinansowywane przez MNiSW w ramach działalności wspomagającej badania.
Polskie Archiwum Medycyny Wewnętrznej jest czasopismem typu "open-access" i gwarantuje darmowy dostęp do pełnej treści artykułów.
Dla redaktorów
Profil kliniczny, rokowanie i leczenie pacjentów z infekcyjnym zapaleniem wsierdzia – 14-letnia obserwacja
Radoslaw Krecki, Jaroslaw Drozdz, Georges Ibata, Piotr Lipiec, Stanislaw Ostrowski, Jaroslaw Kasprzak, Maria Krzeminska-Pakula
Abstrakt
Introduction. Poor prognosis of infective endocarditis (IE) is not only attributable to high morbidity
and mortality during an active phase of the disease, but also to late complications and relapses occurring after
eradication of the infection. Identification of unfavorable prognostic factors allows to optimize therapeutic
modalities in patients with particularly poor prognosis. Objectives. To determine clinical features and long-
-term prognosis among patients with IE. Patients and methods. The study group consisted of 69 IE patients
hospitalized in our center between 1992 and 2005. The diagnosis of IE was based on the Duke University criteria.
The mean age was 52 ±12 years. Surgical treatment was performed in 48 (70%) cases. Results. The etiology
of IE was Staphylococcus sp. in 32% of patients, Streptococcus sp. in 16% of patients, in 41% of cases blood
cultures were negative. The infection was located on the aortic (43%), mitral (26%), tricuspid (8%) and multiple
valves (20%). During 1–14 years of follow-up, 27 patients died (39%). Prognostic factors included NYHA class
of heart failure (p = 0.031), lower left ventricular ejection fraction (p = 0.017), kidney failure (p = 0.012), atrial
fibrillation (p = 0.006), a history of rheumatic valve disease (p = 0.046). In multivariate logistic analysis the only
significant parameter related to poor prognosis after IE was atrial fibrillation. The analysis of receiver operating
characteristic curve showed that patients with atrial fibrillation were significantly associated with higher mortality
(HR 5.35, 95% CI 1.47–19.56, p = 0.011). Conclusions. Regardless of the mode of treatment (medical or
combined medical-surgical), the mortality of patients with infective endocarditis remains relatively high. In this
study atrial fibrillation seems to be the most important risk factor of death.
Słowa kluczowe
infekcja, leczenie, prognoza, wsierdzie
Pol Arch Med Wewn, 2007; 117 (11-12): 512-519
PMID: 18363251
