Serum chemokine growth‑related oncogene α profile during abdominal aortic aneurysm repair. Preliminary report

Monika Jedynak, Andrzej Siemiątkowski, Marek Gacko, Barbara Mroczko, Ewa Grycz

Abstrakt
Introduction High postoperative mortality in patients undergoing aortic abdominal aneurysm (AAA) repair is predominantly associated with ischemia and reperfusion organ injury followed by multiple organ dysfunction syndrome (MODS). Experimental studies have shown a role of growth‑related oncogene α (GROα) chemokine in mediating ischemia‑reperfusion injury and organ damage. Objectives The study evaluated serum GROα levels during elective AAA repair in humans and the relationship between their changes and ischemia‑reperfusion and the postoperative course. Patients and methods Peripheral blood samples were taken from 17 patients before surgery (Preop), before aorta unclamping, 90 minutes after unclamping (90min‑Xoff) and 24 hours after surgery, and from 11 controls. The GROα was measured with an enzyme‑linked immunosorbent assay. Results During AAA repair the GROα level showed an insignificant decrease from 79 pg/ml at Preop to 61 pg/ml at 90min‑Xoff, followed by an increase to 100 pg/ml 24 hours after surgery. In complicated cases the GROα level showed a tendency to higher values during operation and increased to 133 pg/ml 24 h after surgery. Significant positive correlations were found between GROα and duration of surgery (r = 0.317), duration of aorta clamping (r = 0.322) and MOD score (r = 0.417) Conclusion AAA repair is associated with insignificant alterations in the GROα serum level. A decrease in chemokine levels after ischemia and reperfusion may suggest uncomplicated postoperative courses. The tendency to high chemokine levels may be associated with high risk of postoperative organ dysfunction in patients undergoing AAA repair.

Słowa kluczowe
abdominal aortic aneurysm, chemokine, ischemia‑reperfusion

Pol Arch Med Wewn, 2009; 119 (4): 205-210

PMID: 19413178

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