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Redaktor Naczelna ogłasza konkurs na najlepszą studencką pracę oryginalną. Szczegółowe informacje znajdują się tutaj.
Pismo Towarzystwa Internistów Polskich, założone przez prof. Władysława Antoniego Gluzińskiego
Pismo indeksowane w:
MEDLINE/Index Medicus,
EMBASE/Excerpta Medica Database,
Index Copernicus (IC), KBN/MNiSW,
Polish Medical Library (GBL), EBSCO,
ISI Science Citation Index Expanded,
Scopus,
Directory of Open Access Journals (DOAJ)
Wartość Index Copernicus (IC) za 2010: 9 pkt,
punktacja MNiSW: 9 pkt.
Czasopismo dofinansowywane przez MNiSW w ramach działalności wspomagającej badania.
Polskie Archiwum Medycyny Wewnętrznej jest czasopismem typu "open-access" i gwarantuje darmowy dostęp do pełnej treści artykułów.
Dla redaktorów
The +405 GG variant of vascular endothelial growth factor polymorphism is associated with poor prognosis in patients undergoing coronary artery bypass graft surgery
Maciej Pastuszczak, Agnieszka Branicka, Bogdan Jakiela, Ewa Stępień, Andrzej K. Jaworek, Anna Wojas‑Pelc, Bogusław Kapelak, Jerzy Sadowski
Abstrakt
INTRODUCTION: Coronary artery bypass graft (CABG) surgery is associated with systemic response and increased concentrations of numerous cytokines. Vascular endothelial growth factor (VEGF)
related pathway also seems to be involved in inflammatory response induced by CABG. OBJECTIVES: The aim of this study was to analyze the association between the VEGF gene +405 G>C polymorphism (linked to serum VEGF production), and the short‑term clinical outcome during the in‑hospital period (30 days) in patients undergoing CABG. PATIENTS AND METHODS: Genotyping for VEGF gene +405 G>C polymorphism was performed in
64 patients with coronary artery disease at a mean age of 66 years (76.6% males), with a mean EuroSCORE (European System for Cardiac Operative Risk Evaluation) of 2.5 (0–2 points: 50% patients, 3–4: 25%, ≥5 points: 25%), who underwent CABG surgery.
RESULTS: Twenty‑one (33%) patients were homozygous for the +405 G allele, 40 (63%) were heterozygous, and 3 were homozygous
for the +405 C allele. Ten patients died during the 30‑day follow‑up (7 subjects with +405 GG genotype, and the other 3 carriers of the +405 C allele). Using multivariate logistic regression analysis, the risk of death after CABG was increased in patients with +405 GG genotype (odds ratio [OR] = 6.7; 95% confidence interval [CI] 1.5–29.4) and with EuroSCORE ≥5
points (OR = 4.4; 95% CI 1.1–18.1). CONCLUSIONS: The VEGF gene +405 G>C polymorphism might be a prognostic factor of an adverse
postoperative course in patients undergoing CABG surgery. Apart from its proangiogenic action, VEGF may have additional, possibly proinflammatory properties.
Słowa kluczowe
cardiovascular surgery, coronary artery disease, gene polymorphism, prognosis, vascular endothelial growth factor (VEGF)
Pol Arch Med Wewn, 2009; 119 (11): 719-725
PMID: 19920796
Pobierz artykuł (PDF): EN abstrakt PL
